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Why bEVs Outperform Whole Bacterial Cells as biologicals
Whole Bacterial Cells (Conventional biologicals)
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Living organisms → unpredictable behavior in the field
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Depend on survival, colonization, and environmental conditions
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Delayed mode of action (require growth and metabolite production)
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Risk of ecological imbalance and horizontal gene transfer
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More complex and slower regulatory approval pathways
bEVs (EVerse Technology)
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Cell-free system → highly controlled and reproducible, do not require survival or colonization
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Pre-loaded with defined bioactive cargo (proteins, metabolites, RNA)
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Non-replicative → improved biosafety profile
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More stable and easier to formulate and store
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Potentially simplified regulatory pathway
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